With having had both a 22 with a Honda 75 and now a 16 with a Honda 50, I could never think about putting less than a 75 on a 22. This is not a Honda thing but a horsepower thing. The way 22s are built and with 40+ gallons of fuel and 20 gallons of water along with cooking and dining equipment you will accumulate a lot of weight. Then you add in the amount of crosswind a 22 can catch and you will have significant loads to manage. With regard to fuel efficiency, if you keep your speeds down and run a bigger engine in its “sweet spot” you will still get good fuel economy. Two other points, if you have the horsepower and need to get to shelter to beat the weather, you can do it. That can be very important even on lakes. Point 2, and this may not be true of other brands, but the dB level on the 75 (4 cylinder) vs 50 (3 cylinder) seems to be a lot lower, especially if you are above 5000 rpm where you could spend a lot of time on a 22 with a 50.