Agree with all above...don't worry about water pickup.
2 seconds total trim up from a dead stop to best cruising plane is likely far too little for a F150. On the other hand, the only downside is that you're wasting gas and slowing cruise speed by having more hull in the water than needed. (Avoid that if running downsea with large following waves as there is a footnote for every general rule.) There is no substitute for time behind the wheel in your own boat. Calm waters are best for learning the subtle changes control inputs may have. Check your trim gauge at dock or on trailer at full tucked in (negative) trim, should be 1 bar, and at the start of trailering position (sound changes, flashing bar at 5+). The trim sender is a primitive rheostat device between the rams (1 black, 1 pink wire) and activation tab can be adjusted if off. With practice you can tell by the angle of the cowling (looking back) and sound and RPM. At cruise and best trim your splashing will likely appear to be from about 2/3 back from the bow, the antiventilation plate will be awash but not above or under water, and your RPM at 3500 +/- about 500 RPM.
Engine trim is mainly for fore/aft control of how much hull is in the water.
Trim tabs adjust side to side loads and waves (boat will lean into wind and waves otherwise).
One method to determine best trim:
With experienced crew in smooth water, open rear door and with trim full down accelerate from dead stop to 3200 RPM or so and hold there. Then trim up in 1-2 second increments while crew writes down RPM, TRIM, GPS SPEED with each 1-2 second (200 RPM) change. RPM and speed will increase without further throttle. Give each change 10 seconds to take full effect and make some gentle wheel right to left inputs. As you get towards optimum, the higher resistance to turning to the right (in my boat) will decrease, even with power steering.
Eventually you will trim too high and the engines/props will make more/different noise (hard to describe it, but it will be obvious they are less happy) and RPM may increase (props in frothy rather than solid water) but MPH will start to fall off. You can hear it much better with the door open in smooth water. This ventilation (not cavitation) will not harm the engine for this experiment and your engine has a rev limiter @ 6200 RPM.
Trim back down and throttle up to WOT and trim for max speed and note max RPM, which should be as specified for your F150, (5000-6000 RPM for my 2010's) preferably in the higher 50% band (5500-6000).
Again, there is no substitute for hours on your own boat.
Best of luck on the learning curve, have fun, and realize they make both boat and engine fairly idiot-proof at reasonable speeds and conditions.
Choose the latter two for the first 100 hours.
Cheers!
John